Biochem/physiol Actions

Cell permeable: no

Reversible: no

Target IC₅₀: 10 µM against MMP-13

Product does not compete with ATP.

Primary TargetMMP-13

General description

A selective inhibitor of MMP-13 (IC₅₀ = 10 µM). Binds to the S1′ pocket of MMP-13 with its morpholine ring adjacent to the catalytic zinc atom. Does not inhibit MMP-1, MMP-9, and TACE.

A selective inhibitor of MMP-13 (IC₅₀ = 10 µM) that does not appear to act by chelating Zn²⁺. Binds within the entire S1′ pocket of MMP-13, docking with the morpholine ring adjacent to the catalytic zinc atom. Does not inhibit MMP-1, MMP-9, and TACE.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Chen, J.M., et al. 2000. J. Am. Chem. Soc.122, 9648.

Packaging

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)